The information about targets is crucial for Drug Discovery. Few decades back it was tedious to know all the drug targets and information. This information gap had blocked the growth of drug discovery.
Knowing the diseases and selecting right drug targets is crucial for drug discovery. You may have millions of molecules. But if you don't have right targets
then all the synthetic efforts and screening goes waste.
In the bioinformatics era lot of groups try to gather drug targets information.
One of the database which i came across few years back is TTD.
It is a nice, beautiful ,elegant piece of work maintained by NUS, Singapore.
This database currently contains :
- 2,025 targets, including 364 successful, 286 clinical trial, 44 discontinued and 1,331 research targets.
- 17,816 drugs, including 1,540 approved, 1,423 clinical trial, 14,853 experimental drugs and 3,681 multi-target agents (14,170 small molecules and 652 antisense drugs with available strucuture or oligonucleotide sequence).
- Targets and drugs in this database cover 61 protein biochemical class and 140 drug therapeutic classes respectively.
See the above information.
From Second world war to 1990 there were only less than 500 targets. After Human Genome Project, the list has increased to greater than 2000 drug targets. With so much information and knowledge, the number of drugs approved is getting lesser and cost of drug discovery is extremely high.
What is the problem?
Several great scientists and discoverers had written books, articles, gave lectures and speeches about these issues .
In future let us analyse these issues in this blog.
Be tuned to this blog for more information.